Metabolomics Investigator

Website GlaxoSmithKline

Investigator, Metabolomics

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

We have an exciting new position available within the MS Bioimaging group at GSK, based from our world-class R&D site at Collegeville, PA.  Our group is currently building new capabilities to assess spatial metabolomic and lipidomic changes in tissues to provide insight into mechanisms of pharmacology and toxicity.  This new role will focus on development of LC-MS/MS based omics workflows and support integration of this data with non-targeted imaging mass spectrometry (IMS) analyses.  We are looking for a candidate with extensive experience and deep technical expertise in LC-MS/MS based metabolomic and/or lipidomic workflows, specifically in data acquisition, processing, analysis, and interpretation with a broad knowledge of biological pathways. The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients.

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems.  At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities include, but are not limited to:

·       LC-MS/MS based metabolomic and lipidomic workflows in support of non-targeted IMS analyses to deliver functional pharmacology mechanistic endpoints for projects and enhance understanding of biological systems

·       Develop molecular identification strategies using tissue extracts and tissue surface analysis methods (e.g. LESA) to achieve accurate molecular assignment from MALDI imaging data

·       Work in partnership with the Imaging Analytics teams and other stakeholders to build data repositories and custom pipelines to achieve streamlined identification of endogenous biological molecules and cellular pathways, and facilitate broader data reuse

·       Work in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK.

Basic qualifications:

·       PhD in Chemistry, Biology, Physical Sciences, or related discipline.

·       Experience in LC-MS/MS-based metabolomics and/or lipidomics data acquisition and analysis

·       Familiarity and experience with common identification strategies for endogenous biological molecules

·       Experience with troubleshooting and maintaining complex instrumentation

·       Established track record with scientific presentations and publications

Preferred qualifications:

·       Basic understanding of imaging mass spectrometry

·       Experience with Thermo or Bruker mass spectrometers

·       Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

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