Research Fellow in Biological Mass Spectrometry

  • Postdoc
  • Leeds

University of Leeds

We are looking for an outstanding postdoctoral research fellow to join a team of researchers investigating the mechanisms by which membraneless organelles form by phase separation using a combination of structural mass spectrometry, proteomics, biochemistry, biophysics, structural biology and cell biology. You will have experience in the analysis of protein structure, dynamics and assembly using structural mass spectrometry methods (e.g. native mass spectrometry, chemical crosslinking, covalent footprinting and/or hydrogen-deuterium exchange), and complementary biophysical methods. This project focuses on studying the conformational dynamics and early protein-protein and protein-nucleic acid interactions that underlie phase separation mechanisms. In particular, the project will focus on studying the protein TDP-43, which plays a role in in neurodegenerative diseases, including motor neurone disease and dementia, in addition to proteins that form viral replication organelles in Rotavirus-infected cells (NSP5/NSP2). Ultimately, the understanding of membraneless organelle formation afforded by these studies may lead to new treatments for neurodegenerative disease and viral infection.

You will be based in the laboratory of Dr Antonio Calabrese (Sir Henry Dale Fellow), and will work closely with collaborators at Leeds, across the UK and internationally. You will have a PhD (or be close to completion) in Chemistry, Biochemistry, Biophysics or a related discipline. Experience in the use of structural mass spectrometry or proteomics methods is essential and working with cell biological methods would be an advantage.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

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